Nsalu zatsopano zogwiritsidwanso ntchito zimatha kuchotsa zoopsa za chilengedwe ndi mankhwala

Nsalu yopangidwa ndi siponji yopangidwa ndi kristalo yomwe imagwiritsidwa ntchito pochotsa zoopsa zamoyo ndi mankhwala. Chithunzi: Northwestern University
Zipangizo zopangidwa ndi ulusi wa MOF zomwe zimagwira ntchito zambiri zomwe zapangidwa pano zitha kugwiritsidwa ntchito ngati nsalu yoteteza ku zoopsa zamoyo ndi mankhwala.
Nsalu zophera tizilombo komanso zochotsa poizoni zomwe zimagwira ntchito zambiri komanso zongowonjezedwanso zochokera ku N-chloro zimagwiritsa ntchito chimango champhamvu cha zirconium metal organic (MOF)
Zinthu zopangidwa ndi ulusi zimasonyeza kuti mabakiteriya a Gram-negative (E. coli) ndi Gram-positive (Staphylococcus aureus) amagwira ntchito mwachangu motsutsana ndi mabakiteriya onse a Gram-negative (E. coli) ndi Gram-positive (Staphylococcus aureus), ndipo mtundu uliwonse ukhoza kuchepetsedwa ndi ma logarithms 7 mkati mwa mphindi 5.
Zosakaniza za MOF/fiber zodzaza ndi chlorine yogwira ntchito zimatha kuwononga sulfure mustard ndi mankhwala ake a 2-chloroethyl ethyl sulfide (CEES) mwachangu komanso mosankha komanso mwachangu ndi theka la moyo wa mphindi zosakwana 3.
Gulu lofufuza kuchokera ku Northwestern University lapanga nsalu yopangidwa ndi zinthu zambiri zomwe zingathe kuchotsa zoopsa zamoyo (monga kachilombo ka corona komwe kamayambitsa COVID-19) ndi zoopsa za mankhwala (monga zomwe zimagwiritsidwa ntchito pankhondo ya mankhwala).
Nsalu ikawopsezedwa, nsaluyo imatha kubwezeretsedwa momwe inalili poyamba pogwiritsa ntchito njira yosavuta yoyeretsera.
"Kukhala ndi zinthu ziwiri zomwe zimagwira ntchito nthawi imodzi zomwe zimatha kuletsa mankhwala ndi poizoni wachilengedwe ndikofunikira kwambiri chifukwa zovuta zogwirizanitsa zinthu zingapo kuti ntchito iyi ithe ndizambiri," adatero Omar Farha wa ku Northwestern University, yemwe ndi katswiri wa zomangamanga zachitsulo kapena MOF, ndiye maziko a ukadaulo.
Farha ndi pulofesa wa chemistry ku Weinberg School of Arts and Sciences komanso mlembi wa kafukufukuyu. Iye ndi membala wa International Institute of Nanotechnology ku Northwestern University.
Zosakaniza za MOF/fiber zimachokera ku kafukufuku wakale pomwe gulu la Farha linapanga chinthu china chomwe chingathe kuletsa mitsempha ya poizoni. Kudzera mu maopaleshoni ang'onoang'ono, ofufuza amathanso kuwonjezera mankhwala oletsa mavairasi ndi mabakiteriya ku chinthucho.
Faha anati MOF ndi "siponji yosambira yolondola." Zipangizo zazikulu za nano zimapangidwa ndi mabowo ambiri, omwe amatha kugwira mpweya, nthunzi ndi zinthu zina monga siponji zomwe zimasunga madzi. Mu nsalu yatsopano yopangidwa, dzenje la MOF lili ndi chothandizira chomwe chingathe kuletsa mankhwala oopsa, mavairasi ndi mabakiteriya. Zinthu zopangidwa ndi ma nanomaterial zitha kuphimbidwa mosavuta pa ulusi wa nsalu.
Ofufuza adapeza kuti zinthu zopangidwa ndi MOF/fiber zinagwira ntchito mwachangu motsutsana ndi SARS-CoV-2, komanso mabakiteriya a Gram-negative (E. coli) ndi mabakiteriya a Gram-positive (Staphylococcus aureus). Kuphatikiza apo, zinthu zopangidwa ndi MOF/fiber zomwe zili ndi chlorine yogwira ntchito zimatha kuwononga mpweya wa mpiru ndi mankhwala ena ofanana nawo (2-chloroethyl ethyl sulfide, CEES). Ma nanopores a zinthu zopangidwa ndi MOF zomwe zakutidwa ndi nsalu ndi otakata mokwanira kuti thukuta ndi madzi zituluke.
Farha adawonjezera kuti zinthu zopangidwa ndi chigobachi zimatha kukulitsidwa chifukwa zimangofunika zida zoyambira zopangira nsalu zomwe zimagwiritsidwa ntchito m'mafakitale. Zikagwiritsidwa ntchito limodzi ndi chigoba, zinthuzo ziyenera kugwira ntchito nthawi imodzi: kuteteza wovala chigoba ku mavairasi omwe ali pafupi nawo, komanso kuteteza anthu omwe amakumana ndi munthu wodwala amene wavala chigobacho.
Ofufuza amathanso kumvetsetsa malo omwe zinthu zimagwira ntchito pamlingo wa atomu. Izi zimawathandiza iwo ndi ena kupeza ubale wa kapangidwe ndi magwiridwe antchito kuti apange zinthu zina zopangidwa ndi MOF.
Letsani chlorine yogwira ntchito yongowonjezedwanso mu zinthu zopangidwa ndi nsalu za MOF zopangidwa ndi zirconium kuti muchotse zoopsa zamoyo ndi mankhwala. Journal of the American Chemical Society, Seputembala 30, 2021.
Mtundu wa Bungwe Mtundu wa Bungwe Gawo Lachinsinsi/Makampani Maphunziro Boma la Federal Boma/Boma Lapafupi Asilikali Opanda Phindu Atolankhani/Ubale wa Anthu Ena